One-Pot Multicomponent Synthesis of β-Acetamido Ketones Using BF3-Et2O as Catalyst
نویسندگان
چکیده
1 Department of Pharmaceutical Sciences, Singhania University, Jhujhunu-333515, Rajasthan, India. 2 National Institute of Pharmaceutical Education & Research, Raebareli229010, Uttar Pradesh, India. A b s t r a c t Starting from different ketones 1a-1f, aldehyde 2a-2g, and acetonitriles 3a-3d we synthesize some bioactive βAcetamido carbonyl compounds 4a-4h. We also attempted to synthesize these compounds by using phenylacetone and deoxybenzoins in place of ketones to afford the products 4i-4j. 1H-NMR spectra are presented. On the basis of QSAR studies, some compounds were tested for their anti-thrombotic activity in mice. Compound 4f, 4h and 4j were found to exhibit less percentage protection.
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